Current Issue : April - June Volume : 2018 Issue Number : 2 Articles : 2 Articles
Chitosan has been worldwide exploited as a system to fulfill requirements in terms of patient compliance and marvelous therapeutic efficacy. These systems involve precise control over release profile of drug at a specific site in targeted delivery. This review insight on chitosan’s physicochemical and biological characteristics and reflect its role and application pharmaceutical approaches. Chitosan is a unique, effective and advantageous agent with a wide spectrum of desired properties. Recent scientific advancements have employed it as a carrier for most of recent drug delivery systems with marvelous therapeutic interventions. Further studies; unveil the hidden worthy and promising properties of chitosan and its derivatives, to obtain recent delivery systems, hold exciting and fabulous prospects in the near future and also at present....
Mesalamine is used for ulcerative colitis, colon cancer. Microsponges are porous, polymeric microspheres that are designed to deliver a pharmaceutical active ingredient efficiently at the minimum dose and also to, modify drug release. The present work was aimed at designing microsponge based colon specific drug delivery system containing mesalamine, Eudragit RS-100, Eudragit RL-100 based microsponges containing drug in varying amounts were prepared using quasi-emulsion solvent diffusion method. The microsponzes were characterized for production yield, drug content, entrapment efficiency, surface morphology, FTIR, DSC, particle size analysis. The drug release profiles of the microsponge formulations showed matrix type of drug release. In-vitro study revealed that application of mesalamine microsponge formulation caused a significant release after administration of mesalamine microsponge formulation....
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